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Ībrusci P, Vergara-Irigaray M, Johnson S et al (2013) Architecture of the major component of the type III secretion system export apparatus. Due to T3SS relevance in ST pathogenicity, this complex could become a potential target in therapeutic studies as this nanomachine modulates the infection process.Ībby SS, Rocha EPC (2012) The non-flagellar type III secretion system evolved from the bacterial flagellum and diversified into host-cell adapted systems. This paper provided fundamental overview of ST T3SS assembly and regulation, besides summarized the structure and function of this complex. That was possible due to the development of novel techniques, such as X-ray crystallography, cryoelectron microscopy, and nano-gold labelling, which also elucidated the mechanisms behind T3SS assembly and regulation, which was addressed in this review. With a brief and straightforward reading, this review summarized aspects of both ST T3SS, such as its structure and function. To comprise current information about ST T3SS structure and function as well as an overview of its assembly and hierarchical regulation. Among gram-negative bacterium, ST is one of enterica groups predicted to have two T3SSs activated during different phases of infection. enterica serovar Typhimurium (ST) T3SS has been the most characterized so far. This skill allows for gram-negative bacteria to modulate several host cell responses, such as cytoskeleton rearrangement, signal transduction, and cytokine production, which in turn increase the pathogenicity of these bacteria. Type Three Secretion Systems (T3SS) are nanomachine complexes, which display the ability to inject effector proteins directly into host cells.
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